Character Names Game Series Kind of their Relation
Bub & Bob Bust a  Move / Puzzle Bobble Main Protagonists
Morrigan & Lilith Darkstalkers Series One of a kind
Dante & Vergil Devil may Cry Series Brothers, Partners, Enemies
Jimmy & Billy Lee Double Dragon Series Brothers & Protagonists
Cloud & Sephiroth Final Fantasy VII Arch Enemies
Kratos & Zeus God of War Series Father & Son and Arch Enemies
Link & Ganon(dorf) Legend of Zelda Series Protagonist & Antagonist
Link and Navi Legend of Zelda Series Friends, Partners?
Dante & Deadpool Marvel vs Capcom 3 Rivals, Similar Characters
Frost & Sub Zero Mortal Kombat Deadly Alliance Cyromancers / Lin Kuei
Jax & Sonya Blade Mortal Kombat Series Partners
Kitana & Mileena Mortal Kombat Series “Sisters” / Enemies
Quan Chi & Shang Tsung Mortal Kombat Series Partners / Enemies
Raiden & Shao Kahn Mortal Kombat Series Arch Enemies
Scorpion & Sub Zero Mortal Kombat Series Arch Enemies
Date Masamune & Katakura Kojuro Sengoku Basara Series Partners/ Friends
Date Masamune &Yukimura Sanada Sengoku Basara Series Rivals
Amy & Raphael Sorel SoulCalibur Series Lovers?
Balrog & Dudley Street Fighter Series Rivals / Both are Boxers
Cammy White & Chun Li Street Fighter Series Partners / Rivals
Evil Ryu & Oni Akuma Street Fighter Series Powered Up Versions
Hugo & Poison Street Fighter Series Partners
Ryu & Ken Street Fighter Series Friends and Rivals
Yun & Yang Street Fighter Series Brothers
Ryu & Kazuya Mishima SF and Tekken Series Protagonists of Fighting Games
Mario & Bowser Super Mario Series Hero & Villain
Mario & Luigi Super Mario Series Brothers
Anna & Nina Williams Tekken Series Sisters & Rivals


 Other, unusual pairs

Ecco & Sonic