This is Miranda Lawson from the Mass Effect Trilogy, and one of the relative few human females the player can have a romance relationship with in the games.

I never played the ME games, but saw relative many fan art of it and a lot artworks about Miranda as well, the most of them seem to try to illustrate her in a erotic or sexy style, this portray is a real difference.

It was made by Ruthie Hammerschlag as part of her ME game character illustration series.

 

Miranda Lawson from Mass Effect Portrait

Click to enlarge the portrait of Miranda Lawson